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- Title
C<sub>60</sub>-Fullerenes: detection of intracellular photoluminescence and lack of cytotoxic effects.
- Authors
Levi, Nicole; Hantgan, Roy R.; Lively, Mark O.; Carroll, David L.; Prasad, Gaddamanugu L.
- Abstract
We have developed a new method of application of C60 to cultured cells that does not require water-solubilization techniques. Normal and malignant cells take-up C60 and the inherent photoluminescence of C60 is detected within multiple cell lines. Treatment of cells with up to 200 μg/ml (200 ppm) of C60 does not alter morphology, cytoskeletal organization, cell cycle dynamics nor does it inhibit cell proliferation. Our work shows that pristine C60 is non-toxic to the cells, and suggests that fullerene-based nanocarriers may be used for biomedical applications.
- Subjects
FULLERENES; PHOTOLUMINESCENCE; CARBON; CELLS; CELLULAR therapy; CELL proliferation
- Publication
Journal of Nanobiotechnology, 2006, Vol 4, p1
- ISSN
1477-3155
- Publication type
Article
- DOI
10.1186/1477-3155-4-14