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- Title
Effectiveness of Umonium<sup>38</sup> against Burkholderia pseudomallei, Escherichia coli, Pseudomonas aeruginosa and Methicillin-Resistant Staphylococcus aureus (MRSA).
- Authors
Ruanchaiman, Soiratchaneekorn; Amornchai, Premjit; Wuthiekanun, Vanaporn; Langla, Sayan; Maroongruang, Peerapol; Le, Khanh Kim; Blacksell, Stuart D.
- Abstract
Aims: We investigated the antibacterial efficacy of Umonium38 and Virkon® against Burkholderia pseudomallei, Escherichia coli, Pseudomonas aeruginosa and Methicillin-Resistant Staphylococcus aureus (MRSA) up to 14 days following treatment. Methods and results: Umonium38 was diluted to 0.5%, 1.0%, 1.5%, 2.0%, 2.5% and 3%, tested against the bacterial strains at various contact times (15 min to 24 h), and incubated for up to 14 days. A minimum concentration of 0.5% Umonium38 with a contact time of 15 min effectively killed approximately 108 CFU/ml of all four bacterial species. No growth was observed on agar plates from day 0 until day 14 for all six concentrations. The bacteria were also inactivated by a 30-minute treatment time using Virkon® 1% solution. Conclusions: Umonium38 effectively inactivates B. pseudomallei, E. coli, P. aeruginosa and MRSA at a concentration of ≥ 0.5% with a contact time of at least 15 min. The antimicrobial effect of Umonium38 remained for 14 days. Significance: and impact of the study: The study provides evidence supporting the efficacy of Umonium38 as a bactericidal agent against E. coli and P. aeruginosa, specifying the required concentrations and contact time. Our investigation adds to the existing knowledge by demonstrating the bactericidal activity of Umonium38 against B. pseudomallei and MRSA. A limitation of the study is that the results presented have been produced under optimal laboratory conditions, and additional studies are required to determine the effectiveness of Umonium38 and Virkon® under sub-optimal conditions, including high levels of organic matter or variable pH.
- Subjects
BURKHOLDERIA pseudomallei; METHICILLIN-resistant staphylococcus aureus; PSEUDOMONAS aeruginosa; ESCHERICHIA coli; AGAR plates; TREATMENT effectiveness
- Publication
BMC Infectious Diseases, 2024, Vol 24, Issue 1, p1
- ISSN
1471-2334
- Publication type
Article
- DOI
10.1186/s12879-024-09102-9