We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Experimental study on radiation damage of<sup>125</sup>I seeds implanted in canine gastric wall tissue.
- Authors
Ju, Zaishuang; Wang, Zhe; Wang, Lin; Li, Jianxin; Wu, Zhong; Li, Xiang; Wang, Fuguang; Wang, Ruoyu
- Abstract
<bold>Objective: </bold>The objective of the study was to investigate the radiation damage to125 I seeds implanted in canine gastric wall tissue.<bold>Materials and Methods: </bold>Eight beagles were randomly assigned to either the treatment or control group, with four beagles per group. For each beagle in the treatment group, six125 I seeds were implanted in the gastric wall in two rows, spaced at 1.0 cm, with a seed activity of 0.5 mCi and a half-life of 60.2 d. For each beagle in the control group, six 125 I seeds were similarly implanted as a cold source. After implantation, the beagles were scanned by computed tomography (CT) (slice thickness: 2 mm), the region of interest was labeled along the seed boundaries, and postoperative doses were verified. One beagle per group was sacrificed at the 1, 2, 3, and 4 half-lives to be used as gross specimens for observing histological and ultrastructural changes using light microscopy and electron microscopy, respectively.<bold>Results: </bold>Beagles from the treatment group who had125 I radioactive seeds implanted in their stomach walls had the most radiation damage after two half-lives, damage repair began after three half-lives, and the damage was stabilized and further repaired after four half-lives. In the control group, only mild inflammatory reactions were observed around the seeds.<bold>Conclusion: </bold>Appropriate and well-planned implantation of125 I radioactive seeds in beagle stomach walls is safe and reliable.
- Subjects
RADIATION damage; LABORATORY dogs; SEEDS; LOW dose rate brachytherapy; MICROSCOPY; ELECTRON microscopy; CA 125 test; COMPUTED tomography; STOMACH; BIOLOGICAL models; TIME; IODINE radioisotopes; RADIATION doses; RADIOISOTOPE brachytherapy; RADIATION injuries; TUMORS; DOGS; ANIMALS
- Publication
Journal of Cancer Research & Therapeutics, 2020, Vol 16, Issue 2, p203
- ISSN
0973-1482
- Publication type
journal article
- DOI
10.4103/jcrt.JCRT_544_19