We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
A meta-analysis of adoptive immunotherapy in postoperative hepatocellular carcinoma.
- Authors
Zhao, Hui; Zheng, Min; Wang, Kun; Wang, Lianmin; He, Haiyu; Wang, Meilian; Shi, Yanmei; Huang, Songquan; Ji, Fengming; Li, Xiao; Zhu, Hong; Wang, Lin; Zhang, Xiaowen; Shi, Xueyang; Zhao, Songling; Fu, Bimang; Wu, Tao
- Abstract
<bold>Background: </bold>Adoptive immunotherapy (AIT) has been adopted as an adjuvant treatment for hepatocellular carcinoma (HCC) patients after curative therapy. However, the outcomes of AIT remain controversial.<bold>Purpose: </bold>The purpose of this study is to analyze the safety and efficacy of AIT with the recurrence rate and mortality.<bold>Materials and Methods: </bold>We identified eight randomized controlled trials (RCTs) that adopted AIT to HCC after curative treatments. A meta-analysis was carried out to assess the recurrence rate and mortality.<bold>Results: </bold>Eight RCTs with 964 patients were included in the study. The overall analysis showed that AIT treatment can not only decrease the 1-year (risk ratio [RR] =0.59, 95% confidence interval [95% CI] = 0.48-0.72, P < 0.00001), 2-year (RR = 0.69, 95% CI = 0.60-0.79, P < 0.00001), and 3-year (RR = 0.82, 95% CI = 0.74-091, P = 0.0001) recurrence, but also decrease the 1-year (RR = 0.43, 95% CI = 0.30-0.62, P = 0.00001), 2-year (RR = 0.56, 95% CI = 0.46-0.74, P < 0.00001), and 3-year (RR = 0.85, 95% CI = 0.73-0.99, P = 0.03) mortality. The results also indicate that the group of lymphokine-activated killer (LAK) cells showed lower pooled RR values compared to the group of cytokine-induced killer cells among every subgroups. However, the AIT treatment failed to affect the 5-year recurrence rate and mortality (P > 0.05).<bold>Conclusions: </bold>This review provides available evidences that AIT, especially the treatment of LAK, can be used to decrease the early recurrence and mortality of postoperative HCC but may not the long term.
- Subjects
LIVER cancer patients; CANCER immunotherapy; LIVER cancer prevention; META-analysis; CANCER relapse; CANCER risk factors; TUMOR treatment; COMBINED modality therapy; COMPARATIVE studies; HEPATOCELLULAR carcinoma; IMMUNIZATION; LIVER tumors; RESEARCH methodology; MEDICAL cooperation; MORTALITY; POSTOPERATIVE care; RESEARCH; EVALUATION research; TREATMENT effectiveness; PUBLICATION bias; THERAPEUTICS
- Publication
Journal of Cancer Research & Therapeutics, 2018, Vol 14, Issue 4, p807
- ISSN
0973-1482
- Publication type
journal article
- DOI
10.4103/jcrt.JCRT_858_17