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- Title
Contribution of ultrasound-guided fine-needle aspiration cell blocks of metastatic supraclavicular lymph nodes to the diagnosis of lung cancer.
- Authors
Hai-Ying Tian; Dong Xu; Jun-Ping Liu; Wei-Min Mao; Li-Yu Chen; Chen Yang; Li-Ping Wang; Kai-Yuan Shi; Tian, Hai-Ying; Xu, Dong; Liu, Jun-Ping; Mao, Wei-Min; Chen, Li-Yu; Yang, Chen; Wang, Li-Ping; Shi, Kai-Yuan
- Abstract
<bold>Purposes: </bold>Routine smears of fine-needle aspiration (FNA) specimens of supraclavicular lymph nodes with ultrasound (US) real-time guidance have proven useful in lung cancer staging, but the clinical value of additional information from cell-block of FNA samples has been little researched. This study mainly focused on the contribution of cell block analysis to the diagnosis and staging in lung cancer.<bold>Materials and Methods: </bold>Clinical data about 211 lung cancer patients with supraclavicular lymph node enlargement admitted to ultrasonography in the Zhejiang Cancer Hospital and recommended a needle biopsy under US-guided, the adequacy of the specimens for preparing cell blocks was acquireded, and the additional immunohistochemistry or genetic information provided from cell block analysis was examined.<bold>Results: </bold>In 211 lung cancer patients referred for US-guided FNA (median age 61.8 ± 10.0 years, range 30-88) 279 aspirations were performed. Conventional smears could be obtained from 185 aspirates (66.3%) and contained 176 (95.1%) diagnostic smears. Cell blocks could be obtained from 94 aspirates (33.7%) and contained diagnostic material in 88 (93.6%) aspirates. Above all, cell blocks also made epithelial growth factor receptor gene mutation analysis in 17 patients with FNA samples, and the positive rate was 70.6%. Overall, cell blocks provided clinically significant information for 51 of the 211 patients participating in the study (24.2%).<bold>Conclusion: </bold>Cell-block samples from US-guided FNA is a promising, relatively noninvasive technique to provide additional information in lung cancer diagnosis. Analysis of cell blocks allows for genetic analysis of the patients with supraclavicular lymph nodes metastasis.
- Subjects
LUNG cancer; LYMPH node cancer; NEEDLE biopsy; DIAGNOSTIC ultrasonic imaging; IMMUNOHISTOCHEMISTRY; BIOPSY; LUNG tumors; LYMPH nodes; METASTASIS
- Publication
Journal of Cancer Research & Therapeutics, 2015, Vol 11, pC234
- ISSN
0973-1482
- Publication type
journal article
- DOI
10.4103/0973-1482.170544