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- Title
MicroRNA-146a rs2910164 G/C polymorphism and gastrointestinal cancer susceptibility: A meta-analysis based on East Asian population.
- Authors
Bei-Bei Chen; Xin-Guang Cao; Xiao-Bing Chen; Yi-Jie Ma; Wen-Ying Deng; Ning Li; Jin-Xi Huang; Su-Xia Luo; Er-Jiang Zhao
- Abstract
Objective: The relationship between microRNA (miR-146a) rs2910164G/C polymorphism and gastrointestinal cancer susceptibility is not consistent with each other of the published articles. The aim of this meta-analysis was to acquire a more precise effect of the association between the miR-146a rs2910164 G/C polymorphism and gastrointestinal cancer. Materials and Methods: Through searching of the MedLine, Embase, China National Knowledge Infrastructure, and Wanfang databases. Case-control or cohort studies about the relationship between miR-146a rs2910164 G/C polymorphism and gastrointestinal cancer susceptibility were screened and included in this meta-analysis. Quantitative data synthesis was conducted for the associations of miR-146a rs2910164 G/C polymorphism and gastrointestinal cancer risk by statistical software STATA-11.0. Results: Ten studies including 6473 gastrointestinal cancer patients and 7923 controls were identified and included in this meta-analysis. For recessive genetic model (CC vs. CG + GG), people with CG or GG is associated with the susceptibility of gastrointestinal cancer compared with genotype of CC (R = 0.73, 5% confidence interval [CI]: 0.55-0.97, [P= 0.03]); But for dominant model (CC + CG vs. GG) and homozygous model (CC vs. GG), no association of the miR-146a rs2910164G/C polymorphism and gastrointestinal cancer susceptibility were found (dominant: Odds ratio [OR] =0.94, 95% CI: 0.82-1.03, [P= 0.37]; homozygous: OR = 0.85, 95% CI: 0.71-1.03, [P= 0.10]). Sub-group analysis, for homozygous model, people with GG genotype had increased risk of developing colorectal cancer (OR = 0.77, 95% CI: 0.6 4-0.93, [P= 0.008]). Conclusion: No significant association between miR-146a rs2910164G/C polymorphism and gastrointestinal cancer susceptibility was found in this meta-analysis. But for homozygous model, people with GG genotype may have increased risk of developing colorectal cancer.
- Subjects
GASTROINTESTINAL cancer; META-analysis; MICRORNA; GENETIC models; GENOTYPES; GENETICS
- Publication
Journal of Cancer Research & Therapeutics, 2014, Vol 10, pC252
- ISSN
0973-1482
- Publication type
Article
- DOI
10.4103/0973-1482.151462