We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Is low birth weight a risk factor for the development of diabetic nephropathy in patients with type 1 diabetes? A population-based case-control study.
- Authors
Eshoj, O.; Vaag, A.; Borch-Johnsen, K.; Feldt-Rasmussen, B.; Beck-Nielsen, H.
- Abstract
<bold>Objectives: </bold>To investigate if low birth weight as a consequence of intrauterine malnutrition is a risk factor for the later development of diabetic nephropathy.<bold>Design and Subjects: </bold>In a case-control set-up a group of type 1 diabetic subjects with diabetic nephropathy (n = 51) and a matched control group with normal kidney function (n = 51) were compared. Diabetic nephropathy and normal kidney function were defined as urinary albumin excretion rate above 200 microg min-1 and below 20 microg min-1, respectively. The birth weights were all obtained from the midwives' original records.<bold>Setting: </bold>The patients were identified from a population-based study of chronic diabetic complications in the Funen County, Denmark.<bold>Main Outcomes: </bold>Birth weights according to the presence of diabetic nephropathy.<bold>Results: </bold>The median (10-90 percentile) birth weights were 3,600 g (2,960-4,274) in the group with diabetic nephropathy and 3,600 g (2,880-4,220) in the group without nephropathy, P = 0.52. In the lower quartile of birth weights the median (10-90 percentile) birth weights were 3,000 g (2,780-3,200) in the group with nephropathy versus 2,850 g (2,250-3,175) in the group without nephropathy, P = 0.07. In the upper quartile the median (10-90 percentile) birth weights were 4,225 g (4,000-4,741) in the nephropathy group and 4,000 g in the group without nephropathy, P = 0.13. We found no significant correlation between birth weights and log urinary albumin excretion rate (r = 0.148, P = 0.14) and no difference in the number of patients with nephropathy in the lower versus upper quartiles of birth weights.<bold>Conclusion: </bold>We found no evidence of low birth weight as a risk factor for the development of diabetic nephropathy.
- Subjects
LOW birth weight; DIABETIC nephropathies; DIABETES; FETAL diseases; TYPE 1 diabetes; NUTRITION disorders; CASE-control method
- Publication
Journal of Internal Medicine, 2002, Vol 252, Issue 6, p524
- ISSN
0954-6820
- Publication type
journal article
- DOI
10.1046/j.1365-2796.2002.01065.x