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- Title
Proteasomal Oscillation during Mild Heat Shock in Aging Human Skin Fibroblasts.
- Authors
KRAFT, DAVID CHRISTIAN; DEOCARIS, CUSTER C.; RATTAN, SURESH I. S.
- Abstract
Augmentation of proteasome machinery is emerging as a significant gerontomodulatory consequence of hormetic stimulation, such as mild heat stress. This study describes the phenomenon we term hormetic proteasomal oscillation, wherein mildly heat-stressed human fibroblasts (41°C, 1 h) display an adaptation response pattern in proteasome activity. Remarkably, such response appears to be diverse in severely heat-stressed or senescent fibroblasts. This proteasomal oscillation, as an innate cellular reaction to heat and aging, however, is independent of 20S proteasome protein levels and nuclear factor-E2-related factor 2 (Nrf2) transactivation.
- Subjects
SOLAR oscillations; FIBROBLASTS; PHYSIOLOGICAL effects of heat; AGING; PROTEINS; HORMESIS; SKIN
- Publication
Annals of the New York Academy of Sciences, 2006, Vol 1067, Issue 1, p224
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1196/annals.1354.028