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- Title
Long-Term Vascular Responses to Resolute® and Xience V® Polymer-Based Drug-Eluting Stents in a Rabbit Model of Atherosclerosis.
- Authors
HOYMANS, VICKY Y.; VAN DYCK, CHRISTOPHE J.; HAINE, STEVEN E.; FREDERIX, GEERT; FRANSEN, ERIK; TIMMERMANS, JEAN‐PIERRE; VRINTS, CHRISTIAAN J.
- Abstract
Objectives To assess the late postinterventional response to iliac stenting in atheromatous rabbits using the Xience V everolimus-eluting stent (Xience V EES; Abbott Vascular) and the Resolute zotarolimus-eluting stent (Resolute ZES; Medtronic Vascular) with the MultiLink Vision bare metal stent (BMS; Abbott Vascular) as a reference. Background Xience V EES and Resolute ZES were developed to overcome shortcomings of first-generation DES. Methods Functional and microscopic changes were assessed by organ bath experiments and histopathologic examination. Gene expression was investigated using RT-PCR. Results After 91 days, re-endothelialization was nearly complete (BMS: 93 ± 3%; Resolute ZES: 92 ± 2%; Xience V EES: 94 ± 3%; P = 0.10). Neointima thickness was similar in Resolute ZES (0.17 ± 0.08 mm) and BMS (0.17 ± 0.09 mm), and reduced in Xience V EES (0.03 ± 0.01 mm; P < 0.0001). Xience V EES had less peri-strut inflammation compared with BMS (P = 0.001) and Resolute ZES (P = 0.0001), while arterial segments distal to Xience V EES were more sensitive to acetylcholine than those distal to BMS and Resolute ZES (P = 0.02). Lectin-like oxidized receptor-1 was overexpressed in stented arteries (P < 0.001), whereas thrombomodulin was downregulated in Resolute ZES (P = 0.01) and BMS (P = 0.02) compared to unstented arteries of rabbits on regular chow. No significant changes were seen for vascular cell adhesion molecule-1, nitric oxide synthase 3, or endothelin-1. Conclusions At 3-month follow-up, nearly complete re-endothelialization was achieved for all stent groups. Xience V EES induced greater suppression of neointimal growth and peri-strut inflammation, higher vasorelaxation to acetylcholine, and expression of thrombomodulin at the level of unstented controls. (J Interven Cardiol 2014;27:381-390)
- Subjects
RABBIT physiology; ANIMAL models of atherosclerosis; SURGICAL stents; ACETYLCHOLINE; LECTINS; THERAPEUTICS
- Publication
Journal of Interventional Cardiology, 2014, Vol 27, Issue 4, p381
- ISSN
0896-4327
- Publication type
Article
- DOI
10.1111/joic.12128