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- Title
Long term survival after lung transplantation: A single center experience.
- Authors
Blitzer, David; Copeland, Hannah; Roe, David; Hage, Chadi; Wang, I‐Wen; Duncan, Michael; Manghelli, Joshua; Gooch, Danyel; Wozniak, Thomas; Wang, I-Wen
- Abstract
<bold>Background: </bold>There are approximately 2000 lung transplants performed across the United States annually. There is limited data to identify factors predictive of long-term survival.<bold>Objective: </bold>We evaluated 10-year survivors after lung transplant to determine predictors of long-term survival.<bold>Methods: </bold>Data were collected from the United Network for Organ Sharing registry database from a single institution. Inclusion criteria were: patients who received a lung transplant between 1989 and 2005. Descriptive statistics were calculated, and survival outcomes were analyzed using the Kaplan-Meier method.<bold>Results: </bold>Three hundred sixty-one patients received a lung transplant between 1989 and 2005, and 77 patients survived at least 10 years (21%). Diagnoses at the time of transplant included: chronic obstructive pulmonary disease/emphysema 45 (58.4%), idiopathic pulmonary fibrosis 12 (15.6%), alpha 1 anti-trypsin deficiency 6 (7.8%), cystic fibrosis 4 (5.2%), primary pulmonary hypertension 2 (2.6%), and Eisenmenger's syndrome 1 (1.3%). Seventy-four recipients (96.10%) were Caucasian; 46 (59.74%) were female. Age at the time of transplant ranged from 19 to 67 years (mean 50.8; median 52). Forty-two patients (54.5%) were double lung recipients. Survival ranged from 10.0 to 21.9 years (mean 15.5y; median 15.48y). Forty-two (54.5%) subjects are currently alive; the most common causes of death included: chronic rejection (20%), and infection (17.14%).<bold>Conclusions: </bold>Ten-year survivors were significantly younger, weighed less, and had significantly shorter lengths of hospitalization after transplantation. Bilateral lung transplantation was a significant factor in prolonged survival. Survival also improved with institutional experience.
- Subjects
UNITED States; LUNG transplantation; EISENMENGER syndrome; ALPHA 1-antitrypsin deficiency; IDIOPATHIC pulmonary fibrosis; OBSTRUCTIVE lung diseases; ESSENTIAL hypertension; AGE distribution; BODY weight; PULMONARY emphysema; LENGTH of stay in hospitals; TIME; KAPLAN-Meier estimator
- Publication
Journal of Cardiac Surgery, 2020, Vol 35, Issue 2, p273
- ISSN
0886-0440
- Publication type
journal article
- DOI
10.1111/jocs.14163