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- Title
Cyclic isoDGR Peptidomimetics as Low-Nanomolar α<sub>v</sub>β<sub>3</sub> Integrin Ligands.
- Authors
Mingozzi, Michele; Dal Corso, Alberto; Marchini, Mattia; Guzzetti, Ileana; Civera, Monica; Piarulli, Umberto; Arosio, Daniela; Belvisi, Laura; Potenza, Donatella; Pignataro, Luca; Gennari, Cesare
- Abstract
A perfect fit: Shown here is the docking best pose of a low ‐ nanomolar αvβ3 integrin ligand cyclo[DKP ‐ isoDGR] (atom color tube representation; see figure) into the receptor binding pocket, overlaid on the bound conformation of Cilengitide (green tube representation). The extended isoDGR conformation permits all the important interactions with the extracellular domain of the αvβ3 integrin. The metal ion in the MIDAS region is represented by a magenta sphere.
- Publication
Chemistry - A European Journal, 2013, Vol 19, Issue 11, p3563
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201204639