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- Title
Synthesis of Arylidene – Isoquinolinones bearing Combretastatin Skeleton by Cyclocarbopalladation/cross coupling Tandem Heck‐Suzuki Miaura Reactions using nano catalyst Pd@Py‐IL‐SPION.
- Authors
Asgari, Mohammad Sadegh; Rashidi Ranjbar, Parviz; Rahimi, Rahmatollah; Mahdavi, Mohammad
- Abstract
Cyclocarbopalladation/cross‐coupling cascade intramolecular Heck–Suzuki–Miyaura reactions is applied for the first time by palladium immobilized on pyridine‐imidazolium ionic liquid supported magnetic iron oxide nanoparticle catalyst (denoted Pd@Py‐IL‐SPION) for the last step to synthesize trisubstituted arylidene–isoquinolinones derivatives having Combretastatin skeleton. The reaction is performed via propargylamide intermediates prepared by Ugi 4‐CR reactions, which undergoes intramolecular Heck–Suzuki–Miyaura domino reaction to produce the desired trisubstituted arylidene‐isoquinolinones. The method shows full regio‐ and stereoselectivity derives from the particular Pd‐catalyzed syn‐insertion of triple bond.
- Subjects
SUZUKI reaction; SKELETON; CATALYSTS; FERRIC oxide; MAGNETIC fluids; PALLADIUM catalysts; IRON oxide nanoparticles
- Publication
Applied Organometallic Chemistry, 2020, Vol 34, Issue 2, pN.PAG
- ISSN
0268-2605
- Publication type
Article
- DOI
10.1002/aoc.5279