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- Title
Biologically active isoquinoline alkaloids covering 2014–2018.
- Authors
Shang, Xiao‐Fei; Yang, Cheng‐Jie; Morris‐Natschke, Susan L.; Li, Jun‐Cai; Yin, Xiao‐Dan; Liu, Ying‐Qian; Guo, Xiao; Peng, Jing‐Wen; Goto, Masuo; Zhang, Ji‐Yu; Lee, Kuo‐Hsiung
- Abstract
Isoquinoline alkaloids, an important class of N‐based heterocyclic compounds, have attracted considerable attention from researchers worldwide since the early 19th century. Over the past 200 years, many compounds from this class were isolated, and most of them and their analogs possess various bioactivities. In this review, we survey the updated literature on bioactive alkaloids and highlight research achievements of this alkaloid class during the period of 2014–2018. We reviewed over 400 molecules with a broad range of bioactivities, including antitumor, antidiabetic and its complications, antibacterial, antifungal, antiviral, antiparasitic, insecticidal, anti‐inflammatory, antioxidant, neuroprotective, and other activities. This review should provide new indications or directions for the discovery of new and better drugs from the original naturally occurring isoquinoline alkaloids.
- Subjects
ISOQUINOLINE alkaloids; ISOQUINOLINE; CD antigens; HETEROCYCLIC compounds; ALKALOIDS; NINETEENTH century
- Publication
Medicinal Research Reviews, 2020, Vol 40, Issue 6, p2212
- ISSN
0198-6325
- Publication type
Article
- DOI
10.1002/med.21703