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- Title
Tumor volume and subvolume concordance between FDG-PET/CT and diffusion-weighted MRI for squamous cell carcinoma of the cervix.
- Authors
OlsEN, Jeffrey R.; Esthappan, Jacqueline; DeWees, Todd; Narra, Vamsi R.; Dehdashti, Farrokh; Siegel, Barry A.; Schwarz, Julie K.; Grigsby, Perry W.
- Abstract
Purpose: To compare [18F]fluorodeoxyglucose (FDG) / positron emission tomography (PET) / computed tomography (CT) and magnetic resonance imaging (MRI) for evaluating patients with cervical cancer. We compared tumor characteristics on FDG-PET and apparent diffusion coefficient (ADC) maps on diffusion-weighted MRI (DWI) to evaluate concordance of two functional imaging techniques. Materials and Methods: Twenty women with cervical cancer underwent pretreatment FDG-PET/CT and pelvic MRI. Images were rigidly fused by pelvic anatomy using coregistration software. Tumor contours on PET images were generated by autosegmentation of the region containing at least 40% of the maximum standardized uptake value (SUV). DWI contours were generated by manual segmentation. Tumor volume similarity was evaluated using the [PET]/[ADC] volume proportion, Dice's coefficient, and the mean SUV isothreshold at the surface of each ADC contour. Tumor subvolume similarity was evaluated with analysis of variance (ANOVA). Results: The [PET]/[ADC] volume proportion was 0.88 ± 0.14. Dice's coefficient between PET and ADC tumor contours was 0.76 ± 0.06. The mean SUV isothreshold at the ADC-delineated tumor surface was 34 ± 4%. Subvolumes with increased metabolic activity on FDG-PET also had more restricted diffusion on DWI ( P < 0.0001, ANOVA). Conclusion: Concordance of functional imaging was observed between FDG-PET and DWI for cervical cancer. Tumor subvolumes with increased metabolic activity on FDG-PET also have greater cell density by DWI. J. Magn. Reson. Imaging 2013;37:431-434. © 2012 Wiley Periodicals, Inc.
- Publication
Journal of Magnetic Resonance Imaging, 2013, Vol 37, Issue 2, p431
- ISSN
1053-1807
- Publication type
Article
- DOI
10.1002/jmri.23830