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- Title
Natural history of the ossification of cervical posterior longitudinal ligament: a three dimensional analysis.
- Authors
Katsumi, Keiichi; Watanabe, Kei; Izumi, Tomohiro; Hirano, Toru; Ohashi, Masayuki; Mizouchi, Tatsuki; Ito, Takui; Endo, Naoto
- Abstract
<bold>Purpose: </bold>Three-dimensional (3D) imaging using computed tomography (CT) has made it possible to accurately evaluate ossification of the posterior longitudinal ligament (OPLL). Recently, we developed a novel technique to measure ossification volume using the 3D analysis. The purpose of this study was to investigate the natural course of OPLL and the risk factors for volume progression.<bold>Methods: </bold>Forty-one patients (22 males and 19 females) diagnosed with cervical OPLL who had been non-surgically treated were included in this study. We evaluated clinical examination, radiological findings, and the volume of ossified lesions during at least 1-year intervals. Furthermore, we performed risk factor analysis for OPLL volume progression.<bold>Results: </bold>The mean ossification volume was 2047.4 ± 1437.3 mm3 in the first examination and 2201.0 ± 1524.1 mm3 in the final examination, indicating a significant increase during the follow-up period (p < 0.001). The mean annual rate of lesion increase was 4.1 ± 2.7%. Univariate regression analysis demonstrated significant relationships between the annual rate of lesion increase and age (β = -0.48; p = 0.001), body weight (BW) (β = 0.36; p = 0.02), and body mass index (BMI) (β = 0.35; p = 0.03). Furthermore, age was the only significant predictor of OPLL progression (R2 = 0.23; p = 0.001) in multivariate liner regression analysis.<bold>Conclusions: </bold>Younger age, higher BW, and higher BMI are predictors of OPLL progression. Younger age is the most significant predictor in non-surgically treated patients.
- Subjects
POSTERIOR longitudinal ligament; THREE-dimensional display systems; RADIOGRAPHY; PRECANCEROUS conditions; CERVIX uteri diseases; DIAGNOSIS; CERVICAL vertebrae; COMPUTED tomography; METAPLASTIC ossification; THREE-dimensional imaging; PILOT projects; DISEASE progression; LONGITUDINAL ligaments
- Publication
International Orthopaedics, 2018, Vol 42, Issue 4, p835
- ISSN
0341-2695
- Publication type
journal article
- DOI
10.1007/s00264-017-3667-z