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- Title
Anti-Periodontitis Effects of Dendropanax morbiferus H.Lév Leaf Extract on Ligature-Induced Periodontitis in Rats.
- Authors
Yang, Ye jin; Song, Jun-Ho; Yang, Ju-Hye; Kim, Min Jung; Kim, Kwang Youn; Kim, Jin-Kyoung; Jin, Yeung Bea; Kim, Woo Hyun; Kim, Suk; Kim, Ki-Rim; Park, Kwang Il; Lee, Hu-Jang
- Abstract
Periodontitis is caused by pathogens in the oral cavity. It is a chronic infectious disease that causes symptoms including gingival bleeding and tooth loss resulting from the destruction of periodontal tissues coupled with inflammation. Dendropanax morbiferus H.Lév (DM) is a natural product that exhibits various biological activities with few side effects. In this study, the potential of DM leaf hot-water extracts (DMWE) as a treatment for periodontitis was determined and its anti-oxidant and anti-inflammatory effects were evaluated. Compounds in DMWE were identified by high-performance liquid chromatography (HPLC) and nitric oxide (NO) and prostaglandin E2 (PGE2) production was measured in RAW 264.7 cells. We measured the gingival index and gingival sulcus depth, and micro-CT was performed in vivo using a ligature-induced periodontitis rat model, which is similar to human periodontitis. The DMWE-treated group exhibited a decrease in cytokine concentration and relieved the gingival index and gingival sulcus depth compared with the periodontitis-induced control group. In addition, micro-CT and histological analysis revealed that DMWE exhibited anti-inflammatory effects and improved alveolar bone loss in periodontitis-induced rats. These findings suggest that DMWE has excellent anti-oxidant and anti-inflammatory effects that protect and prevent periodontal tissue damage and tooth loss caused by the inflammatory response.
- Subjects
PERIODONTITIS; BONE resorption; HIGH performance liquid chromatography; GINGIVAL hemorrhage; X-ray computed microtomography
- Publication
Molecules, 2023, Vol 28, Issue 2, p849
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules28020849