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- Title
Axl, Immune Checkpoint Molecules and HIF Inhibitors from the Culture Broth of Lepista luscina.
- Authors
Kotajima, Mihaya; Choi, Jae-Hoon; Kondo, Mitsuru; D'Alessandro-Gabazza, Corina N.; Toda, Masaaki; Yasuma, Taro; Gabazza, Esteban C.; Miwa, Yukihiro; Shoda, Chiho; Lee, Deokho; Nakai, Ayaka; Kurihara, Toshihide; Wu, Jing; Hirai, Hirofumi; Kawagishi, Hirokazu
- Abstract
Two compounds 1 and 2 were isolated from the culture broth of Lepista luscina. This is the first time that compound 1 was isolated from a natural source. The structure of compound 1 was identified via 1D and 2D NMR and HRESIMS data. Compounds 1 and 2 along with 8-nitrotryptanthrin (4) were evaluated for their biological activities using the A549 lung cancer cell line. As a result, 1 and 2 inhibited the expression of Axl and immune checkpoint molecules. In addition, compounds 1, 2 and 4 were tested for HIF inhibitory activity. Compound 2 demonstrated statistically significant HIF inhibitory effects on NIH3T3 cells and 1 and 2 against ARPE19 cells.
- Subjects
IMMUNE checkpoint proteins; LUNG cancer
- Publication
Molecules, 2022, Vol 27, Issue 24, p8925
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27248925