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- Title
"On Water" Palladium Catalyzed Direct Arylation of 1H-Indazole and 1H-7-Azaindazole.
- Authors
Gambouz, Khadija; El Abbouchi, Abdelmoula; Nassiri, Sarah; Suzenet, Franck; Bousmina, Mostapha; Akssira, Mohamed; Guillaumet, Gérald; El Kazzouli, Saïd
- Abstract
The C3 direct arylation of 1H-indazole and 1H-7-azaindazole has been a significant challenge due to the lack of the reactivity at this position. In this paper, we describe a mild and an efficient synthesis of new series of C3-aryled 1H-indazoles and C3-aryled 1H-7-azaindazoles via a C3 direct arylation using water as solvent. On water, PPh3 was effective as a ligand along with a lower charge of the catalyst Pd(OAc)2 (5 mol%) at 100 °C, leading to C3-aryled 1H-indazoles or C3-aryled 1H-7-azaindazoles in moderate to good yields.
- Subjects
ARYLATION; PALLADIUM; CATALYSTS; WATER; WATER use
- Publication
Molecules, 2020, Vol 25, Issue 12, p2820
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25122820