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- Title
Silymarin: Friend or Foe of UV Exposed Keratinocytes?
- Authors
Fidrus, Eszter; Ujhelyi, Zoltán; Fehér, Pálma; Hegedűs, Csaba; Janka, Eszter Anna; Paragh, György; Vasas, Gábos; Bácskay, Ildikó; Remenyik, Éva; Delmas, Dominique
- Abstract
The application of natural plant extracts in UV-protection is popular and intensively studied. Silymarin (from Silibum marianum), a naturally occurring polyphenol, has recently received attention due to its antioxidant, anti-inflammatory and anti-apoptotic effects. However, its role in the UV-mediated keratinocyte cell response is still controversial. In this study, we investigated the effects of Silibum marianum extracts with different origins and formulations on UVA-exposed HaCaT keratinocytes in vitro. Our results show, that silymarin treatment caused an inverse dose-dependent photosensitivity relationship (at higher doses, a decrease in cell viability and ROS production) after UVA exposure. The attenuation of the UVA-induced ROS generation after silymarin treatment was also observed. Moreover, silymarin pre-treatment increased the cyclobutane pyrimidine dimer photolesions in keratinocytes after UVA exposure. These results indicated the dual role of silymarin in UVA-exposed keratinocytes. It scavenges ROS but still induces phototoxicity. Based on our results dermatological applications of silymarin and related compounds should be considered very carefully.
- Subjects
SILYMARIN; KERATINOCYTES; ANTIOXIDANTS; CYCLOBUTANE; PHOTOSENSITIVITY
- Publication
Molecules, 2019, Vol 24, Issue 9, p1652
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules24091652