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- Title
New Xanthone from the Bark Extract of Rheedia acuminata and Antiplasmodial Activity of Its Major Compounds.
- Authors
Guillaume^Marti; Véronique^Eparvier; Marc^Litaudon; Grellier, Philippe; Guéritte, Françoise
- Abstract
Bioassay-guided fractionation of the ethyl acetate bark extract of Rheedia acuminata led to the isolation of the new compound 1,5,6-trihydroxy-3-methoxy-7- geranyl-xanthone (1), together with four known compounds 2-5. These compounds were tested in vitro for their antiplasmodial activity on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) and for their cytotoxicity against the human diploid embryonic lung cell line MRC-5.
- Subjects
BARK; PLASMODIUM falciparum; BIOLOGICAL assay; CELL lines; CELL-mediated cytotoxicity
- Publication
Molecules, 2010, Vol 15, Issue 10, p7106
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules15107106