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- Title
Antioxidant Activity of Butyl- and Phenylstannoxanes Derived from 2-, 3- and 4-Pyridinecarboxylic Acids.
- Authors
Corona-Bustamante, Alicia; Viveros-Paredes, Juan Manuel; Flores-Parra, Angelina; Peraza-Campos, Ana Lilia; Martínez-Martínez, Francisco J.; Sumaya-Martínez, María Teresa; Ramos-Organillo, Ángel
- Abstract
In vitro antioxidant activity for 12 stannoxanes derived from Ph3SnCl (compounds 1-3), Ph2SnCl2 (compounds 4-6), Bu3SnCl (compounds 7-9), and Bu2SnCl2 (compounds 10-12), was assayed qualitatively by the chromatographic profile with 1,1- diphenyl-2-picrylhydrazil (DPPH) method and by two quantitative methods: the DPPH radical scavenging activity and Ferric-Reducing Antioxidant Power (FRAP) assays. The results were compared with those obtained with the starting materials 2-pyridinecarboxylic acid (I), 3-pyridinecarboxylic acid (II) and 4-pyridinecarboxylic acid (III), as well as with standard compounds, such as vitamin C and vitamin E, respectively. The in vitro antiradical activity with DPPH of diphenyltin derivative 5 showed a very similar behavior to vitamin C at a 20 μg//mL concentration, whereas according to the FRAP method, compound 8 was better. This difference is due to the mechanism of the antioxidant process. The Structure-Activity Relationships (SAR) for both methods is also reported .
- Subjects
STRUCTURE-activity relationships; NIACIN; ANTIOXIDANTS; ORGANOTIN compounds; METAL complexes; CHROMATOGRAPHIC analysis; BIOLOGICAL assay
- Publication
Molecules, 2010, Vol 15, Issue 8, p5445
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules15085445