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- Title
Antimalarial and Cytotoxic Phenolic Compounds from Cratoxylum maingayi and Cratoxylum cochinchinense.
- Authors
Laphookhieo, Surat; Maneerat, Wisanu; Koysomboon, Sorwaporn
- Abstract
Nine phenolic compounds isolated from Cratoxylum maingayi and C. cochinchinense were evaluated for anti-malarial activity against Plasmodium falciparum, and for cytotoxic activity against the NCI-H187 (human small cell lung cancer) cancer cell line. Formoxanthone C (3) was found to be the most active against the NCI-H187 cancer cell line, with an IC50 of 0.22 μg/mL, while vismione B (7) had the highest activity against Plasmodium falciparum, with an IC50 of 0.66 μg/mL.
- Subjects
PHENOLS; ANTIMALARIALS; PLASMODIUM falciparum; ANTINEOPLASTIC antibiotics; LUNG diseases; SMALL cell lung cancer; CELL lines; PROTOZOAN diseases; CANCER cells
- Publication
Molecules, 2009, Vol 14, Issue 4, p1389
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules14041389