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- Title
Calves are susceptible to infection with the newly emerged porcine deltacoronavirus, but not with the swine enteric alphacoronavirus, porcine epidemic diarrhea virus.
- Authors
Jung, Kwonil; Hu, Hui; Saif, Linda
- Abstract
Fecal virus shedding, seroconversion and histopathology were evaluated in 3-7-year-old gnotobiotic calves orally inoculated with porcine deltacoronavirus (PDCoV) (9.0-9.6 log genomic equivalents [GE] of OH-FD22-P5; n=4) or porcine epidemic diarrhea virus (PEDV) (10.2-12.5 log GE of PC21A; n=3). In PDCoV-inoculated calves, an acute but persisting fecal viral RNA shedding and PDCoV-specific serum IgG antibody responses were observed, but without lesions or clinical disease. However, no fecal shedding, seroconversion, histological lesions, and clinical disease were detected in PEDV-inoculated calves. Our data indicate that calves are susceptible to infection by the newly emerged PDCoV, but not by the swine coronavirus, PEDV.
- Subjects
PORCINE epidemic diarrhea virus; DISEASE susceptibility; VIRAL shedding; SEROCONVERSION; CALVES; CATTLE diseases; IMMUNOGLOBULIN G; HISTOPATHOLOGY
- Publication
Archives of Virology, 2017, Vol 162, Issue 8, p2357
- ISSN
0304-8608
- Publication type
Report
- DOI
10.1007/s00705-017-3351-z