We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Placental and Germ Cell Alkaline Phosphatase RFLPs and Haplotypes Associated with Spontaneous Abortion.
- Authors
Wennberg, C.; Kivelä, A.; Holmgren, P.-Å.
- Abstract
Placental alkaline phosphatase (PLAP) and germ cell alkaline phosphatase (GCAP) are controlled by closely linked genes on chromosome 2q34-q37. In previous investigations, associations have been found between PLAP types and spontaneous abortion. In this study, PLAP and GCAP RFLPs and haplotypes were found to show highly significant associations with spontaneous abortions in the Finnish and Swedish populations. However, different associations were found in the Finnish and Swedish populations. The Finnish abortions were associated with the GCAP allele PstI(b) 2 and the Swedish abortions with the PLAP allele Pstl(a) 2. A possible mechanism behind the associations may therefore be linkage disequilibria with deleterious alleles within or close to the alkaline phosphatase gene complex. Copyright © 1995 S. Karger AG, Basel
- Publication
Human Heredity, 1995, Vol 45, Issue 5, p272
- ISSN
0001-5652
- Publication type
Article
- DOI
10.1159/000154313