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- Title
Antidiabetic Activity of Afobazole in Wistar Rats.
- Authors
Ostrovskaya, R. U.; Ivanov, S. V.; Voronin, M. V.; Ozerova, I. V.; Zolotov, N. N.; Seredenin, S. B.
- Abstract
Using the streptozotocin model of type 2 diabetes mellitus in Wistar rats, we compared antidiabetic activity of anxiolytic Afobazole with that of metformin. Afobazole in a dose of 10 mg/kg reduced streptozotocin-induced hyperglycemia and polyphagia and prevented accumulation of malonic dialdehyde, being not inferior to metformin in a dose of 300 mg/kg, and was even more effective than metformin in body weight recovery, elimination of polydipsia, and preservation of these effects after treatment withdrawal.
- Subjects
LABORATORY rats; STREPTOZOTOCIN; METFORMIN; DRUG efficacy; DIABETES
- Publication
Bulletin of Experimental Biology & Medicine, 2018, Vol 165, Issue 5, p649
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-018-4233-4