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- Title
Antiangiogenic Effects of Nerve Growth Factor Loop 4 Monomeric Dipeptide Mimetic.
- Authors
Kryzhanovskii, S.; Antipova, T.; Tsorin, I.; Pekeldina, E.; Nikolaev, S.; Sorokina, A.; Miroshkina, I.; Gudasheva, T.; Seredenin, S.
- Abstract
The effects of GK-1, a monomeric dipeptide mimetic of nerve growth factor (NGF) loop 4, on angiogenesis were studied in vitro and in vivo. Experiments on human umbilical vein endothelial cells HUVEC showed that the test compound did not affect tubulogenesis (initial stage of angiogenesis) and prevented realization of the angiogenic effect of NGF and its dimeric dipeptide mimetic GK-2. Experiments on rat hind limb ischemia model demonstrated that GK-1 (1 mg/kg/day intraperitoneally over 14 days) significantly reduced the density of the capillary network in ischemic tissue and increased the number and area of Zenker necrosis in comparison with the control. These data suggest that GK-1 exhibits a pronounced antiangiogenic activity.
- Subjects
NERVE growth factor; NEOVASCULARIZATION; DIPEPTIDES; NECROSIS; UMBILICAL veins
- Publication
Bulletin of Experimental Biology & Medicine, 2017, Vol 163, Issue 1, p49
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-017-3735-9