We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Screening of Some Dioxaboreninopyridine and Aniline Derivatives for Carcinogenic Properties Using a Model Cell-Free System of Regenerating Rat Liver.
- Authors
Syatkin, S.; Kirichuk, A.; Soldatenkov, A.; Kutyakov, S.; Neborak, E.; Shevkun, N.; Kuznetsova, O.; Skorik, A.; Terent'ev, A.
- Abstract
We studied the effects of some aniline and dioxaborininopyridine derivatives on the rate of oxidative deamination of putrescine and polyamines in a tissue with high mitotic index. These effects were evaluated quantitatively by measuring diamine oxidase and polyamine oxidase activities in a model cell-free test system of regenerating rat liver tissue. Aniline derivatives exhibited mainly antiproliferative effects and promoted oxidative degradation of putrescine, spermidine, and spermine. Dioxaborininopyridine derivatives inhibited this process, thus exhibiting carcinogenic properties.
- Subjects
PYRIDINE derivatives; ANILINE derivatives; CARCINOGENICITY testing; CIRCULATING tumor DNA; LIVER regeneration; LABORATORY rats
- Publication
Bulletin of Experimental Biology & Medicine, 2017, Vol 162, Issue 6, p801
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-017-3717-y