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- Title
Levocarnitine Normalizes Elevated Blood Level of Soluble Fas mRNA in Patients with Acute Myocardial Infarction.
- Authors
Novikov, D.; Belousov, S.; Karaulov, A.; Eroshevskaya, N.; Shumilova, S.; Kasatova, E.; Kazatskaya, Zh.; Novikov, V.
- Abstract
Fas-induced apoptosis plays an important role in the mechanisms of tissue injury in myocardial infarction. The level of membrane Fas mRNA was elevated during the postinfarction period in the blood of patients and did not change in response to levocarnitine. The mRNA level of soluble Fas, inhibiting Fas-dependent apoptosis, remained normal during the first 7 days, but increased 14 days after myocardial infarction, which corresponded to previously detected increase of serum level of soluble Fas molecules. Addition of levocarnitine, inhibiting Fas-dependent apoptosis, to therapy caused no changes in the level of soluble Fas mRNA, presumably because of similar effects of soluble Fas and levocarnitine on the apoptotic processes in myocardial infarction.
- Subjects
MESSENGER RNA; MYOCARDIAL infarction; MYOCARDIAL infarction treatment; APOPTOTIC bodies; APOPTOSIS; PATIENTS; PHYSIOLOGY
- Publication
Bulletin of Experimental Biology & Medicine, 2015, Vol 158, Issue 5, p617
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-015-2820-1