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- Title
New insights into the aetiology of colorectal cancer from genome-wide association studies.
- Authors
Tenesa, Albert; Dunlop, Malcolm G.
- Abstract
Genome-wide association studies have recently identified ten common genetic variants associated with colorectal cancer susceptibility, several suggesting the involvement of components of the transforming growth factor beta (TGFbeta) superfamily signalling pathway. To date, no causal sequence variants have been identified, and risk seems to be mediated through effects on gene regulation. Several markers are located close to poorly characterized genes or in gene deserts, raising challenges for elucidating mechanisms of susceptibility. Disease-associated common genetic variation offers the potential to refine risk stratification within populations and enable more targeted disease prevention strategies.
- Subjects
HUMAN genetic variation; COLON cancer; ETIOLOGY of diseases; TRANSFORMING growth factors-beta; GENETIC markers; GENETIC research
- Publication
Nature Reviews Genetics, 2009, Vol 10, Issue 6, p353
- ISSN
1471-0056
- Publication type
journal article
- DOI
10.1038/nrg2574