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- Title
Mouse models of male infertility.
- Authors
Cooke, Howard J; Saunders, Philippa T K
- Abstract
Spermatogenesis is a complex process that involves stem-cell renewal, genome reorganization and genome repackaging, and that culminates in the production of motile gametes. Problems at all stages of spermatogenesis contribute to human infertility, but few of them can be modelled in vitro or in cell culture. Targeted mutagenesis in the mouse provides a powerful method to analyse these steps and has provided new insights into the origins of male infertility.
- Subjects
TESTIS physiology; CELL differentiation; TESTIS; GERM cells; ANIMALS; BIOLOGICAL models; CELL physiology; FOLLICLE-stimulating hormone; HUMAN reproduction; INFERTILITY; LUTEINIZING hormone; LUTEINIZING hormone releasing hormone; MICE; PHYSIOLOGY; ANATOMY
- Publication
Nature Reviews Genetics, 2002, Vol 3, Issue 10, p790
- ISSN
1471-0056
- Publication type
journal article
- DOI
10.1038/nrg911