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- Title
Role of tenascin-C in articular cartilage.
- Authors
Masahiro Hasegawa; Toshimichi Yoshida; Akihiro Sudo
- Abstract
Tenascin-C (TN-C) is a glycoprotein component of the extracellular matrix (ECM). TN-C consists of four distinct domains, including the tenascin assembly domain, epidermal growth factor-like repeats, fibronectin type III-like repeats, and the fibrinogen-like globe (FBG) domain. This review summarizes the role of TN-C in articular cartilage. Expression of TN-C is associated with the development of articular cartilage but markedly decreases during maturation of chondrocytes and disappears almost completely in adult articular cartilage. Increased expression of TN-C has been found at diseased cartilage and synovial sites in osteoarthritis (OA) and rheumatoid arthritis (RA). TN-C is increased in the synovial fluid in patients with OA and RA. In addition, serum TN-C is elevated in RA patients. TN-C could be a useful biochemical marker for joint disease. The addition of TN-C results in different effects among TN-C domains. TN-C fragments might be endogenous inducers of cartilage matrix degradation; however, full-length TN-C could promote cartilage repair and prevent cartilage degeneration. The deficiency of TN-C enhanced cartilage degeneration in the spontaneous OA in aged joints and surgical OA model. The clinical significance of TN-C effects on cartilage is not straightforward.
- Subjects
TENASCIN; ARTICULAR cartilage; EXTRACELLULAR matrix; EPIDERMAL growth factor; SYNOVIAL fluid; BIOMARKERS
- Publication
Modern Rheumatology, 2018, Vol 28, Issue 2, p215
- ISSN
1439-7595
- Publication type
Article
- DOI
10.1080/14397595.2017.1349560