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- Title
HISTOPATHOLOGICAL AND CYTOGENETIC EFFECTS OF COPPER OXIDE NANOPARTICLES IN THE MICE AFTER ORAL ADMINISTRATION.
- Authors
Haleem, Azhar M.; Khaleel, Hadeel K.
- Abstract
The current study was conducted to investigate the histopathological and toxic effects of Copper oxide nanoparticles (CuONPs), which were synthesized by using Q-switched pulsed Nd: YAG laser ablation. CuONPs were synthesized by using Qswitched pulsed Nd: YAG laser ablation of a pure copper sheet submerged in aqueous media, their toxicity was studied on the albino mice Mus musculus by oral administration for twenty male albino mice that divided into four groups (5 male per cage). Four different doses of CuONPs (0, 25, 50 and 100) mg\kg were used. The animals were given the CuONPs once a day for one week, while the control group exposed to Distilled Water (DW). The acute toxicity was investigated by Histopathological changes for both liver and kidney of exposed animals beside genotoxic effects by investigation bone marrow cells' mitotic index (MI) and total chromosomal aberration (TCA). From findings the histological analyses refer to real histopath in liver in all doses, hepatocytes rupture, and dilated blood sinusoids in high dose (100) mg/kg accumulation of chronic inflammatory cells were noticed, while kidney tissue suffered from renal capsule damage, enlargement in glomerulus, loses in urinary space associated with cytoplasmic vacuolization. Cytogenetic parameters affected by this treated by a reduction in proliferative bone marrow index and elevation total chromosomal abnormalities. CuONPs not completely safe and has toxicity on internal organs of exposed mice also cytogenetic parameters showed significant cytotoxic effects on bone marrow cells of mice by reduction of Mitotic index (MI), and induced structural chromosomal changes.
- Subjects
HISTOPATHOLOGY; CYTOGENETICS; COPPER oxide; NANOPARTICLES; RAT diseases
- Publication
Biochemical & Cellular Archives, 2020, Vol 20, Issue 2, p6259
- ISSN
0972-5075
- Publication type
Article