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- Title
ASSOCIATION BETWEEN AR GENE CAG REPEAT POLYMORPHISM AND SOME BIOCHEMICAL PARAMETERS WITH POLYCYSTIC OVARY SYNDROME IN IRAQI WOMEN.
- Authors
Kamil, Rasha M.; Hasan, Bushra F.; Khalaf, Ilham A.; Mohammad, Huda M.
- Abstract
CAG repeat in androgen receptor gene is one of very important genetic research to polycystic ovary syndrome (PCOS). Several studies have been presented to approve the association between AR gene (CAG) repeat polymorphism and PCOS patients without any reliable results. The aim of the present study was to estimate whether there is an alteration or relation in the AR gene (CAG) repeat length between patients with PCOS and healthy control in Iraqi women. Sixty Iraqi women with PCOS and thirty healthy women as a control were recruited in our research. Assays of biochemical parameters serum follicle-stimulating-hormone (FSH), serumluteinizing-hormone (LH), serum prolactin-hormone (PRL) and serum testosteronehormone (T) were carried out, also BMI, age and hyper androgenism signs were recorded. PCR based assays were used to genotype of AR gene (CAG) repeat alleles. We detected that the CAG biallelic mean were comparable in PCOS women and controls (20.77±0.65 vs. 20.87±0.80, P = 0.626). While when CAG biallelic repeats were divided into two groups; (short (CAG) repeat ≤20 and long (CAG) repeat >20), the (CAG) repeat biallelic mean displayed more frequent in PCOS than in controls (60% vs 30%, P<0.0024). In patients group, short (CAG) repeat was higher frequency 36/60 (60%) than long (CAG) repeat 24/60 (40%). Also, in patients serum testosterone (T) were positively correlated with the (CAG) repeat length polymorphism (r = 0.26, P = 0.001), while the clinical signs of hyperandrogenism with patients were showed a higher effect in short (CAG) repeat ≤ 20 alleles than long (CAG) repeat > 20 alleles as in hirsutism (30/43), acne (25/33) alopecia (27/38) and oily skin (18/ 31). Distribution of AR gene (CAG) repeats varied between patients with PCOS and controls, our finding results support the principle that there is a relation between AR gene (CAG) repeat polymorphism and PCOS in Iraqi women and (CAG) repeat polymorphism share in hyper androgenism in women with PCOS.
- Subjects
POLYCYSTIC ovary syndrome; ANDROGEN receptors; HYPERANDROGENISM; GENETIC polymorphisms; BODY mass index
- Publication
Biochemical & Cellular Archives, 2020, Vol 20, Issue 1, p709
- ISSN
0972-5075
- Publication type
Article
- DOI
10.35124/bca.2020.20.1.709