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- Title
Constructing an Axonal-Specific Myelin Developmental Graph and its Application to Childhood Absence Epilepsy.
- Authors
Drenthen, Gerhard S.; Fonseca Wald, Eric L. A.; Backes, Walter H.; Aldenkamp, Albert P.; Vermeulen, R. Jeroen; Debeij‐van Hall, Mariette H. J. A.; Klinkenberg, Sylvia; Jansen, Jacobus F. A.; Debeij-van Hall, Mariette H J A
- Abstract
<bold>Background and Purpose: </bold>The process of myelination starts in utero around 20 weeks of gestation and continues through adulthood. We first set out to characterize the maturation of the tract-specific myelin content in healthy subjects from childhood (7-12 years) into adulthood (18-32 years). Second, we apply the resulting development graph to children with childhood absence epilepsy (CAE), a pediatric epilepsy that was previously characterized by changes in myelin content.<bold>Methods: </bold>In a prospective cross-sectional study, 15 healthy children (7-12 years), 14 healthy adult participants (18-32 years) and 17 children with a clinical diagnosis of CAE (6-12 years) were included. For each participant, diffusion weighted images were acquired to reconstruct bundles of white matter tracts and multi-echo multi-slice GRASE images were acquired for myelin-water estimation. Subsequently, a tract-specific myelin development graph was constructed using the percentual difference in myelin-water content from childhood (12 year) to adulthood (25 year).<bold>Results: </bold>The graph revealed myelination patterns, where tracts in the central regions myelinate prior to peripheral tracts and intra-hemispheric tracts as well as tracts in the left hemisphere myelinate prior to inter-hemispheric tracts and tracts in the right hemisphere, respectively. No significant differences were found in myelin-water content between children with CAE and healthy children for neither the early developing tracts, nor the tracts that develop in a later stage. However, the difference between the myelin-water of late and early developing tracts is significantly smaller in the children with CAE.<bold>Conclusion: </bold>These results indicate that CAE is associated with widespread neurodevelopmental myelin differences.
- Subjects
CHILDHOOD epilepsy; MYELIN; CHILD development; OLIGODENDROGLIA; WHITE matter (Nerve tissue); MYELINATION; DIFFUSION magnetic resonance imaging; BRAIN; NEURONS; PETIT mal epilepsy; CROSS-sectional method; MAGNETIC resonance imaging; NERVE tissue; LONGITUDINAL method
- Publication
Journal of Neuroimaging, 2020, Vol 30, Issue 3, p308
- ISSN
1051-2284
- Publication type
journal article
- DOI
10.1111/jon.12707