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- Title
Sequential MR Assessment of the Susceptibility Vessel Sign and Arterial Occlusion in Acute Stroke.
- Authors
Ritzenthaler, Thomas; Lacalm, Audrey; Cho, Tae‐Hee; Maucort‐Boulch, Delphine; Klaerke Mikkelsen, Irene; Ribe, Lars; Østergaard, Leif; Hjort, Niels; Fiehler, Jens; Pedraza, Salvador; Louis Tisserand, Guy; Baron, Jean‐Claude; Berthezene, Yves; Nighoghossian, Norbert
- Abstract
<bold>Purpose: </bold>Susceptibility vessel sign (SVS) may likely influence recanalization after thrombolysis. We assessed, through the European sequential MRI database "I-KNOW," the relationship between the presence of SVS on T2-weighted gradient echo imaging, its angiographic counterpart on magnetic resonance angiography and its subsequent impact on recanalization after thrombolysis.<bold>Materials and Methods: </bold>Initial clinical and MRI characteristics and early follow up were analyzed in acute ischemic stroke patients treated with rt-Pa within 4.5 hours. Patients underwent multimodal MRI at admission. Sequential imaging performed 3 hours, 2 days and 1 month later allowed the analysis of SVS changes and recanalization.<bold>Results: </bold>Fifty patients were included in the study. SVS was observed in 54% of cases at admission. SVS was still present in 46% patients at 3 hours, 16% at 2 days, and 0% at 1 month. It was an independent predictor of no recanalization after thrombolysis (P = .04). After 3 hours, SVS disappeared in only 4 cases, and was not linked with recanalization on MRA. Conversely, when SVS persisted, a partial or complete recanalization was observed in 9 and 6 cases, respectively.<bold>Conclusions: </bold>SVS is a predictor of lower recanalization rate. Its disappearance is not necessarily correlated with recanalization.
- Subjects
ARTERIAL occlusions; STROKE patients; THROMBOLYTIC therapy; MAGNETIC resonance imaging; MEDICAL databases; TISSUE plasminogen activator; HEMOGLOBINS; PROGNOSIS; STATISTICS; STROKE; TREATMENT effectiveness; MAGNETIC resonance angiography; THERAPEUTICS
- Publication
Journal of Neuroimaging, 2016, Vol 26, Issue 3, p355
- ISSN
1051-2284
- Publication type
journal article
- DOI
10.1111/jon.12312