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- Title
Effect of intrauterine infusion of ceftiofur on uterine health and conception rate in dairy cows.
- Authors
Galvao, K. N.; Greco, L. F.; Vilela, J. M.; Santos, J. E. P.
- Abstract
Objectives were to determine the effects of intrauterine infusion of ceftiofur hydrochloride on uterine health and conception rate in lactating cows. Holstein cows, 830, at 44 d in milk (DIM), were blocked by parity, treatment of any illness in the first 44 DIM, and treatment of acute puerperal metritis (PM) by intrauterine infusion of 2.5 g of oxytetracycline and, within each block, randomly assigned to one of two treatments: IUIC, intrauterine infusion of 125 mg of ceftiofur hydrochloride at 44 DIM; Control, no intrauterine infusion. All cows received two injections of 25 mg of PGF2a 14 days apart, at 37 and 51 DIM, and cows not detected in estrus and inseminated 14 days after the second PGF2a were enrolled in a timed AI protocol (d 65, 100 µg of GnRH; d 72, 25 mg of PGF2a; d 73, 1 mg of ECP; d 75, timed AI). Body condition was scored in all cows at 44 DIM. A subset of 206 cows had their vaginal mucus scored (0 = clear, 1 = mucupurulent or purulent) on d 44, and had uterine fluid harvested on d 51 for cytology and bacteriology. Pregnancy was diagnosed on d 38 after AI. Pregnancy data is available for 486 cows. The conception rate was similar (P = 0.29) for the IUIC and Control groups (42.9 vs 47.2 %). Conception was greater (P = 0.05) for primiparous than multiparous (49.7 vs 35.8%) and for cows that did not have PM (45.6 vs 43.8 %). When only cows that had PM were evaluated (n=146), those infused with oxytetracycline early postpartum tended (P = 0.09) to have greater conception rate than cows not infused (47.1 vs 28.0 %). The proportion of cows with positive uterine culture at 51 DIM was similar (P = 0.26) between IUIC and controls (25.3 vs 32.4 %), but IUIC decreased (P = 0.04) the proportion of cultures positive for Archanobacterium pyogenes (1.0 vs 7.4 %). Cows with mucus score 1 had greater (P < 0.05) proportion of A. pyogenes, Escherichia coli and overall positive cultures. Intrauterine infusion of ceftiofur hydrochloride reduced prevalence of infection by A. pyogenes, but did not improve conception rate of dairy cows.
- Subjects
COWS; ESTRUS; CONCEPTION; DAIRY farms; ESCHERICHIA coli
- Publication
Journal of Animal Science, 2006, Vol 84, p9
- ISSN
0021-8812
- Publication type
Article