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- Title
Effect of periodontal therapy on the course of cyclosporin-induced gingival overgrowth: role of ABCB1 and PAI-1 gene polymorphisms.
- Authors
De Iudicibus, Sara; Stocco, Gabriele; Castronovo, Gaetano; Pico, Camillo; Racano, Roberto; Borelli, Massimo; Bevilacqua, Lorenzo; Di Lenarda, Roberto; Bartoli, Fiora; Decorti, Giuliana
- Abstract
Objectives: Etiological periodontal therapy is effective in reducing cyclosporin A-induced gingival overgrowth, but a high variability among subjects has been observed. This study aimed to evaluate the role of polymorphisms in PAI-1 and A BCB1 genes on the course of this side effect following periodontal therapy. Method and Materials: Forty-five transplant patients were subjected to nonsurgical periodontal therapy and evaluated for hypertrophy index, probing depths, bleeding, and plaque scores at baseline, and after 3 and 6 months. A BCB1 (C3435T and G2677T) and PAI-1 (4G/5G) polymorphisms were studied with polymerase chain reaction-restriction fragment length polymorphism and allele-specific polymerase chain reaction respectively. Results: All the monitored periodontal indexes decreased significantly during the six months. Modeling of hypertrophy index by linearmixed- effect models (allowing non-normal distribution of the outcome variable hypertrophy index) resulted in the selection as the most significant model, of the one comprising the independent variables: time, C 3435T genotype, and their interaction term. This model indicated that C 3435T-mutated patients had significantly higher baseline hypertrophy index values (90% Markov chain Monte Carlo empirical confidence intervals: 5.08, 30.00). The decrease in hypertrophy index values over time showed a trend toward being faster in mutated than nonmutated patients (interaction time: C 3435T nonmutated, 90% Markov chain Monte Carlo empirical confidence interval: -11.08, -0.40). When hypertrophy index values were normalized, the significance and trend were lost. No effect of the A BCB1 G2677T and PAI-1 4G/5G polymorphisms was observed.Conclusion: These preliminary results suggest that C 3435T polymorphism is a genetic factor that could influence the course of cyclosporin A-induced gingival overgrowth in transplant patients subjected to periodontal therapy.
- Subjects
CONFIDENCE intervals; GENETIC polymorphisms; HEALTH outcome assessment; PERIODONTAL disease; POLYMERASE chain reaction; SCALES (Weighing instruments); STATISTICS; DATA analysis; TREATMENT effectiveness; PRE-tests &; post-tests; REPEATED measures design; DATA analysis software; CYCLOSPORINS; DESCRIPTIVE statistics
- Publication
Quintessence International, 2013, Vol 44, Issue 3, p249
- ISSN
0033-6572
- Publication type
Article
- DOI
10.3290/j.qi.a29052