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- Title
Virilizing Adrenocortical Carcinoma Oncocytic Variant in a Child with Heterosexual Precocious Puberty and a Literature Review.
- Authors
Bulut, Seyran; Çatlı, Gönül; Filibeli, Berna Eroğlu; Manyas, Hayrullah; Ayrancı, İlkay; Meral, Rabia; Kızmazoğlu, Deniz; Dündar, Bumin Nuri
- Abstract
Androgen-secreting adrenal tumors are aggressive cancers in childhood; however, they are rare in clinical practice. Children with adrenal carcinoma usually present with peripheral precocious puberty, premature pubarche, signs of virilization and clitoromegaly. We present a case of 4 year-old girl with premature pubarche, clitoromegaly and bone age advancement, who was subsequently diagnosed with pure androgensecreting oncocytic adrenal carcinoma. After the removal of the adrenal tumor, our patient developed precocious puberty. In patients with functioning adrenocortical carcinoma who have had surgical removal, clinical follow-up and hormonal marker examination for the secondary effects of excessive hormone secretion at least every 2 or 3 months may be a useful option after surgery. The aim of this article is to emphasize that adrenal tumors can be seen in patients presenting with virilization findings. We also present a literature review of these tumors, which are very rare in childhood.
- Subjects
VIRILISM; HETEROSEXUALITY; PRECOCIOUS puberty; ADENOCARCINOMA; HYPERADRENOCORTICISM; VULVAR diseases; DEXAMETHASONE; ADRENAL tumors
- Publication
Journal of Pediatric Research, 2022, Vol 9, Issue 3, p307
- ISSN
2147-9445
- Publication type
Article
- DOI
10.4274/jpr.galenos.2022.05579