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- Title
GMMA Is a Versatile Platform to Design Effective Multivalent Combination Vaccines.
- Authors
Micoli, Francesca; Alfini, Renzo; Di Benedetto, Roberta; Necchi, Francesca; Schiavo, Fabiola; Mancini, Francesca; Carducci, Martina; Palmieri, Elena; Balocchi, Cristiana; Gasperini, Gianmarco; Brunelli, Brunella; Costantino, Paolo; Adamo, Roberto; Piccioli, Diego; Saul, Allan
- Abstract
Technology platforms are an important strategy to facilitate the design, development and implementation of vaccines to combat high-burden diseases that are still a threat for human populations, especially in low- and middle-income countries, and to address the increasing number and global distribution of pathogens resistant to antimicrobial drugs. Generalized Modules for Membrane Antigens (GMMA), outer membrane vesicles derived from engineered Gram-negative bacteria, represent an attractive technology to design affordable vaccines. Here, we show that GMMA, decorated with heterologous polysaccharide or protein antigens, leads to a strong and effective antigen-specific humoral immune response in mice. Importantly, GMMA promote enhanced immunogenicity compared to traditional formulations (e.g., recombinant proteins and glycoconjugate vaccines), without negative impact to the anti-GMMA immune response. Our findings support the use of GMMA as a "plug and play" technology for the development of effective combination vaccines targeting different bugs at the same time.
- Subjects
COMBINED vaccines; HUMORAL immunity; ANTI-infective agents; RECOMBINANT proteins; MIDDLE-income countries
- Publication
Vaccines, 2020, Vol 8, Issue 3, p540
- ISSN
2076-393X
- Publication type
Article
- DOI
10.3390/vaccines8030540