We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Sequential Granulocyte-Macrophage Colony-Stimulating Factor Inhalation after Whole-Lung Lavage for Pulmonary Alveolar Proteinosis. A Report of Five Intractable Cases.
- Authors
Shinya Ohkouchi; Keiichi Akasaka; Toshio Ichiwata; Shu Hisata; Hideya Iijima; Toshinori Takada; Hiroki Tsukada; Hideaki Nakayama; Jun-ichi Machiya; Toshiya Irokawa; Hiromasa Ogawa; Yoko Shibata; Masakazu Ichinose; Masahito Ebina; Toshihiro Nukiwa; Hajime Kurosawa; Koh Nakata; Ryushi Tazawa; Ohkouchi, Shinya; Akasaka, Keiichi
- Abstract
Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare disease characterized by the excessive accumulation of surfactant proteins within the alveolar spaces and by higher titers of autoantibodies to granulocyte-macrophage colony-stimulating factor (GM-CSF) in the serum and bronchoalveolar lavage fluid. The antibodies inhibit the maturation and phagocytosis of alveolar macrophages. Although the standard therapy for aPAP has been whole-lung lavage (WLL), this procedure is invasive and needs to be repeated for several years. GM-CSF inhalation therapy is a new procedure for treating aPAP and can induce remission with less invasiveness, although it is generally less effective in severe cases. We evaluated five cases with remarkable improvement by using sequential GM-CSF inhalation therapy after WLL; however, the treatment failed when this therapy preceded WLL. Therefore, sequential GM-CSF inhalation after WLL may reinforce the efficiency of WLL in patients with severe aPAP.
- Publication
Annals of the American Thoracic Society, 2017, Vol 14, Issue 8, p1298
- ISSN
2329-6933
- Publication type
journal article
- DOI
10.1513/AnnalsATS.201611-892BC