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- Title
Single-nucleotide polymorphisms in the class II region of the major histocompatibility complex in Japanese patients with immunoglobulin A nephropathy.
- Authors
Akiyama, F.; Tanaka, T.; Yamada, R.; Ohnishi, Y.; Tsunoda, T.; Maeda, S.; Takei, T.; Obara, W.; Ito, K.; Honda, K.; Uchida, K.; Tsuchiya, K.; Nitta, K.; Yumura, W.; Nihei, H.; Ujiie, T.; Nagane, Y.; Miyano, S.; Suzuki, Y.; Fujioka, Tomoaki
- Abstract
Immunoglobulin A nephropathy (IgAN) is a form of chronic glomerulonephritis of unknown etiology and pathogenesis. Immunogenetic studies have not conclusively indicated that human leukocyte antigen (HLA) is involved. As a first step in investigating a possible relationship between HLA class II genes and IgAN, we analyzed the extent of linkage disequilibrium (LD) in this region of chromosome 6p21.3 in a Japanese test population and found extended LD blocks within the class II locus. We designed a case-control association study of singlenucleotide polymorphisms (SNPs) in each of those LD blocks, and determined that SNPs located in the HLADRA gene were significantly associated with an increased risk of IgAN (P = 0.000001, odds ratio = 1.91 [95% confidence interval 1.46-2.49]); SNPs in other LD blocks were not. Our data imply that some haplotype of the HLADRA locus has an important role in the development of IgAN in Japanese patients.
- Subjects
GENETIC polymorphisms; IMMUNOGLOBULIN A; IGA glomerulonephritis
- Publication
Journal of Human Genetics, 2002, Vol 47, Issue 10, p532
- ISSN
1434-5161
- Publication type
Article
- DOI
10.1007/s100380200080