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- Title
High Azole Resistance in Aspergillus fumigatus Isolates from Strawberry Fields, China, 2018.
- Authors
Yong Chen; Fengshou Dong; Jingya Zhao; Hong Fan; Chunping Qin; Runan Li; Verweij, Paul E.; Yongquan Zheng; Li Han; Chen, Yong; Dong, Fengshou; Zhao, Jingya; Fan, Hong; Qin, Chunping; Li, Runan; Zheng, Yongquan; Han, Li
- Abstract
In 2018, we conducted a cross-sectional study to investigate azole resistance in environmental Aspergillus fumigatus isolates obtained from different agricultural fields in China. Using 63 soil cores, we cultured for azole-resistant A. fumigatus and characterized isolates by their cyp51A gene type, short tandem repeat genotype, and mating type. Of 206 A. fumigatus isolates, 21 (10.2%) were azole resistant. Nineteen of 21 had mutations in their cyp51A gene (5 TR34/L98H, 8 TR34/L98H/S297T/F495I, 6 TR46/Y121F/T289A). Eighteen were cultured from soil samples acquired from strawberry fields, suggesting this soil type is a potential hotspot for azole resistance selection. Twenty resistant isolates were mating type MAT1-1, suggesting asexual sporulation contributed to their evolution. Prochloraz, difenoconazole, and tebuconazole were the most frequently detected fungicides in soil samples with azole-resistant fungus. Our study results suggest that managing the fungicides used in agriculture will help contain the problem of antifungal drug resistance in clinics.
- Subjects
CHINA; ASPERGILLUS fumigatus; MICROSATELLITE repeats; STRAWBERRIES; SOIL classification; SOIL sampling; SOIL fungi; PULMONARY aspergillosis; RESEARCH; DNA; MICROBIAL ecology; BIOLOGICAL evolution; SEQUENCE analysis; PESTICIDES; CROSS-sectional method; RESEARCH methodology; MEDICAL cooperation; EVALUATION research; COMPARATIVE studies; GENETIC techniques; DRUG resistance in microorganisms; ASPERGILLUS; MICROBIAL sensitivity tests
- Publication
Emerging Infectious Diseases, 2020, Vol 26, Issue 1, p81
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid2601.190885