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- Title
Definition of Chronic Pulmonary Aspergillosis in Resource-Constrained Settings.
- Authors
Denning, David W.; Page, Iain D.; Chakaya, Jeremiah; Jabeen, Kauser; Jude, Cecilia M.; Cornet, Muriel; Alastruey-Izquierdo, Ana; Bongomin, Felix; Bowyer, Paul; Chakrabarti, Arunaloke; Gago, Sara; Guto, John; Hochhegger, Bruno; Hoenigl, Martin; Irfan, Muhammad; Irurhe, Nicholas; Izumikawa, Koichi; Kirenga, Bruce; Manduku, Veronica; Moazam, Samihah
- Abstract
Chronic pulmonary aspergillosis (CPA) is a recognized complication of pulmonary tuberculosis (TB). In 2015, the World Health Organization reported 2.2 million new cases of nonbacteriologically confirmed pulmonary TB; some of these patients probably had undiagnosed CPA. In October 2016, the Global Action Fund for Fungal Infections convened an international expert panel to develop a case definition of CPA for resource-constrained settings. This panel defined CPA as illness for >3 months and all of the following: 1) weight loss, persistent cough, and/or hemoptysis; 2) chest images showing progressive cavitary infiltrates and/or a fungal ball and/or pericavitary fibrosis or infiltrates or pleural thickening; and 3) a positive Aspergillus IgG assay result or other evidence of Aspergillus infection. The proposed definition will facilitate advancements in research, practice, and policy in lower- and middle-income countries as well as in resource-constrained settings.
- Publication
Emerging Infectious Diseases, 2018, Vol 24, Issue 8, pe1
- ISSN
1080-6040
- Publication type
Article
- DOI
10.3201/eid2408.171312