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- Title
Influenza A(H7N9) Virus Antibody Responses in Survivors 1 Year after Infection, China, 2017.
- Authors
Mai-Juan Ma; Cheng Liu; Meng-Na Wu; Teng Zhao; Guo-Lin Wang; Yang Yang; Hong-Jing Gu; Peng-Wei Cui; Yuan-Yuan Pang; Ya-Yun Tan; Hui Hang; Bao Lin; Jiang-Chun Qin; Li-Qun Fang; Wu-Chun Cao; Li-Ling Chen; Ma, Mai-Juan; Liu, Cheng; Wu, Meng-Na; Zhao, Teng
- Abstract
Avian influenza A(H7N9) virus has caused 5 epidemic waves in China since its emergence in 2013. We investigated the dynamic changes of antibody response to this virus over 1 year postinfection in 25 patients in Suzhou City, Jiangsu Province, China, who had laboratory-confirmed infections during the fifth epidemic wave, October 1, 2016-February 14, 2017. Most survivors had relatively robust antibody responses that decreased but remained detectable at 1 year. Antibody response was variable; several survivors had low or undetectable antibody titers. Hemagglutination inhibition titer was >1:40 for <40% of the survivors. Measured in vitro in infected mice, hemagglutination inhibition titer predicted serum protective ability. Our findings provide a helpful serologic guideline for identifying subclinical infections and for developing effective vaccines and therapeutics to counter H7N9 virus infections.
- Subjects
H7N9 Influenza; EPIDEMICS; IMMUNOGLOBULINS; BLOOD agglutination; AVIAN influenza; INFLUENZA epidemiology; ANIMAL experimentation; COMPARATIVE studies; HISTORY; HOSPITAL care; INFLUENZA; RESEARCH methodology; MEDICAL cooperation; MICE; RESEARCH; SERODIAGNOSIS; VIRAL antibodies; EVALUATION research; INFLUENZA A virus
- Publication
Emerging Infectious Diseases, 2018, Vol 24, Issue 4, p663
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid2404.171995