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- Title
Dissemination of Clonally Related Escherichia coli Strains Expressing Extended-Spectrum β-Lactamase CTX-M-15.
- Authors
Coque, Teresa M.; Novais, Ângela; Carattoli, Alessandra; Poirel, Laurent; Pitout, Johann; Peixe, Luísa; Baquero, Fernando; Cantón, Rafael; Nordmann, Patrice
- Abstract
We analyzed 43 CTX-M-15-producing Escherichia coli isolates and 6 plasmids encoding the blaCTX-M-15 gene from Canada, India, Kuwait, France, Switzerland, Portugal, and Spain. Most isolates belonged to phylogroups B2 (50%) and D (25%). An EC-B2 strain of clonal complex sequence type (ST) 131 was detected in all countries; other B2 isolates corresponded to ST28, ST405, ST354, and ST695 from specific areas. EC-D strains were clonally unrelated but isolates from 3 countries belonged to ST405. All CTX-M-15 plasmids corresponded to IncFII group with overrepresentation of 3 HpaI-digested plasmid DNA profiles (A, B and C; 85-120kb, similarity ≥70%). Plasmid A was detected in EC-B2 strains (ST131, ST354, or ST405), plasmid C was detected in B2 and D strains, and plasmid B was confined to worldwide-disseminated ST131. Most plasmids contained blaOXA-1, aac(6')-Ib-cr, and blaTEM-1. Worldwide dissemination of CTX-M-15 seems to be determined by clonal complexes ST131 and ST405 and multidrug-resistant IncFII plasmids.
- Subjects
ESCHERICHIA coli; BETA lactamases; AMIDASES; MICROBIAL enzymes; ESCHERICHIA; PLASMIDS
- Publication
Emerging Infectious Diseases, 2008, Vol 14, Issue 2, p195
- ISSN
1080-6040
- Publication type
Article
- DOI
10.3201/eid1402.070350