We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Immunization with heterologous flaviviruses protective against fatal West Nile encephalitis.
- Authors
Tesh, Robert B.; da Rosa, Amelia P.A. Travassos; Guzman, Hilda; Araujo, Tais P.; Shu-Yuan Xiao; Travassos da Rosa, Amelia P A; Xiao, Shu-Yuan
- Abstract
Prior immunization of hamsters with three heterologous flaviviruses (Japanese encephalitis virus [JEV] SA14-2-8 vaccine, wild-type St. Louis encephalitis virus [SLEV], and Yellow fever virus [YFV] 17D vaccine) reduces the severity of subsequent West Nile virus (WNV) infection. Groups of adult hamsters were immunized with each of the heterologous flaviviruses; approximately 30 days later, the animals were injected intraperitoneally with a virulent New York strain of WNV. Subsequent levels of viremia, antibody response, and deaths were compared with those in nonimmune (control) hamsters. Immunity to JEV and SLEV was protective against clinical encephalitis and death after challenge with WNV. The antibody response in the sequentially infected hamsters also illustrates the difficulty in making a serologic diagnosis of WNV infection in animals (or humans) with preexisting Flavivirus immunity.
- Subjects
HAMSTERS; ENCEPHALITIS; IMMUNIZATION
- Publication
Emerging Infectious Diseases, 2002, Vol 8, Issue 3, p245
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid0803.010238