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- Title
Antenatal magnesium sulfate and the postnatal response of the ductus arteriosus to indomethacin in extremely preterm neonates.
- Authors
Katayama, Y.; Minami, H.; Enomoto, M.; Takano, T.; Hayashi, S.; Lee, Y. K.
- Abstract
Objective:The aim of this study is to evaluate the influence of antenatal magnesium sulfate (MgSO4) treatment on the clinical responsiveness of the ductus arteriosus to indomethacin prophylaxis and on that of symptomatic patent ductus arteriosus (sPDA) to indomethacin treatment in premature neonates.Study Design:This is a retrospective study of 160 consecutively admitted neonates with a gestational age of <28 weeks (41 MgSO4 exposed and 119 controls) who received indomethacin prophylaxis.Result:Incidence of early closure of the ductus arteriosus was lower in the MgSO4-exposed neonates than in the control group (59 vs 84%, respectively; P=0.002), whereas incidence of an sPDA was higher (46 vs 24%, respectively; P=0.006). Response to indomethacin treatment was similar between the two groups. Logistic regression analysis indicated increased risk of failure of early ductus arteriosus closure following antenatal MgSO4 treatment (odds ratio, 4.03; P=0.002).Conclusion:In extremely preterm neonates, antenatal MgSO4 treatment reduces clinical responsiveness of the ductus arteriosus to indomethacin prophylaxis but not that of sPDA to indomethacin treatment.
- Subjects
MAGNESIUM sulfate; INDOMETHACIN; CHI-squared test; COMPUTER software; CONFIDENCE intervals; EPIDEMIOLOGY; FISHER exact test; PREMATURE infants; MULTIVARIATE analysis; PATENT ductus arteriosus; PRENATAL care; STATISTICS; U-statistics; LOGISTIC regression analysis; DATA analysis; RETROSPECTIVE studies; THERAPEUTICS
- Publication
Journal of Perinatology, 2011, Vol 31, Issue 1, p21
- ISSN
0743-8346
- Publication type
Article
- DOI
10.1038/jp.2010.62