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- Title
Protective Effect of a Chrysanthemum indicum containing Formulation in Cadmium-Induced Ototoxicity.
- Authors
Kim, Su-Jin; Myung, Noh-Yil; Shin, Bong-Gi; Lee, Jeong-Han; So, Hong-Seob; Park, Rae-Kil; Um, Jae-Young; Hong, Seung-Heon
- Abstract
Chungshinchongyitang (CSCYT) is an herbal drug formula containing Chrysanthemum indicum and 13 other herbs used for treating auditory diseases. Irreversible hearing loss is a characteristic effect of a number of heavy metals. Cadmium (Cd2+) is an environmental contaminant that causes a variety of adverse effects. In the present study, we investigate the protective effects of CSCYT against Cd2+ induced ototoxicity in vitro and ex vivo. The findings of this study show that CSCYT prevents the destruction of hair cell arrays induced by Cd2+ in the rat organ of Corti primary explants. CSCYT inhibited cell death, release of cytochrome c and generation of reactive oxygen species induced by Cd2+ in HEI-OC1 auditory cell line. In addition, we also demonstrated that CSCYT exerted its effect by modulating of apoptosis via the caspase-3 activation and extracellular signal-regulated kinase activation. These results are expected to improve the understanding of the pharmacological mechanism of CSCYT and aid in the development of potential therapeutic strategies against ototoxicity.
- Publication
American Journal of Chinese Medicine, 2011, Vol 39, Issue 3, p587
- ISSN
0192-415X
- Publication type
Journal Article