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- Title
Increase of EEG Spectral Theta Power Indicates Higher Risk of the Development of Severe Cognitive Decline in Parkinson's Disease after 3 Years.
- Authors
Cozac, Vitalii V.; Hatz, Florian; Meyer, Antonia; Fuhr, Peter; Gschwandtner, Ute; Chaturvedi, Menorca
- Abstract
Objective: We investigated quantitative electroencephalography (qEEG) and clinical parameters as potential risk factors of severe cognitive decline in Parkinson's disease. Methods: We prospectively investigated 37 patients with Parkinson's disease at baseline and follow-up (after 3 years). Patients had no severe cognitive impairment at baseline. We used a summary score of cognitive tests as the outcome at followup. At baseline we assessed motor, cognitive, and psychiatric factors; qEEG variables [global relative median power (GRMP) spectra] were obtained by a fully automated processing of high-resolution EEG (256-channels). We used linear regression models with calculation of the explained variance to evaluate the relation of baseline parameters with cognitive deterioration. Results: The following baseline parameters significantly predicted severe cognitive decline: GRMP theta (4-8 Hz), cognitive task performance in executive functions and working memory. Conclusions: Combination of neurocognitive tests and qEEG improves identification of patients with higher risk of cognitive decline in PD.
- Subjects
PARKINSON'S disease; ELECTROENCEPHALOGRAPHY; MILD cognitive impairment; COHORT analysis; DEMENTIA
- Publication
Frontiers in Aging Neuroscience, 2016, Vol 8, p1
- ISSN
1663-4365
- Publication type
Article
- DOI
10.3389/fnagi.2016.00284