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- Title
Iron(III) Catecholates for Cellular Imaging and Photocytotoxicity in Red Light.
- Authors
Basu, Uttara; Pant, Ila; Khan, Imran; Hussain, Akhtar; Kondaiah, Paturu; Chakravarty, Akhil R.
- Abstract
Iron(III) complexes [Fe(L)(L')(NO3)]-in which L is phenyl-N,N-bis[(pyridin-2-yl)methyl]- methanamine (1), (anthracen-9-yl)- N,N-bis[(pyridin-2-yl)methyl]methanamine (2), (pyreny-1-yl)-N,N-bis[(pyridin- 2-yl)methyl]methanamine (3-5), and L' is catecholate (1-3), 4-tert-butyl catecholate (4), and 4-(2-aminoethyl)- benzene-1,2-diolate (5)-were synthesized and their photocytotoxic properties examined. The five electron-paramagnetic complexes displayed a FeIII/ FeII redox couple near -0.4 V versus a saturated calomel electrode (SCE) in DMF/0.1M tetrabutylammonium perchlorate (TBAP). They showed unprecedented photocytotoxicity in red light (600-720 nm) to give IC50≈15 mm in various cell lines by means of apoptosis to generate reactive oxygen species. They were ingested in the nucleus of HeLa and HaCaT cells in 4 h, thereby interacting favorably with calf thymus (ct)-DNA and photocleaving pUC19 DNA in red light of 785 nm to form hydroxyl radicals.
- Subjects
CELL imaging; IRON; APOPTOSIS; DNA; PHOTODYNAMIC therapy
- Publication
Chemistry - An Asian Journal, 2014, Vol 9, Issue 9, p2494
- ISSN
1861-4728
- Publication type
Article
- DOI
10.1002/asia.201402207